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Orlistats main drawback is digestive: because the unabsorbed fat has to go somewhere, side effects like oily or loose bowel movements are common (especially after fatty meals)
It also provides the clinical foundation for asking whether adding glucagon receptor activation can further increase efficacy
The results also demonstrated how retatrutide decreased stress markers in insulin-producing cells
Calcitonin levels, the biomarker that would rise if human C-cells responded to GLP-1 stimulation, remain stable during treatment
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