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This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and produces abnormally large red cells called megaloblasts (and hypersegmented neutrophils) with abundant cytoplasm capable of RNA and protein synthesis, but with clumping and fragmentation of nuclear chromatin

Finally, behavioral assessments were limited to specific domains and the observed biochemical changes cannot be interpreted as evidence of global neuroprotection, since behavioral deficits persisted and some molecular markers were negatively affected by treatment

Liposomal glutathione is preferred because standard capsules are often broken down by stomach acid before they can be absorbed

Conversely, male patients often exhibit normal overall ROS levels in their lymphocytes but show profound, specific mitochondrial lipid oxidative damage