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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

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174 Pyroptosis occurs through the formation of bubble-like protrusions, also known as pyroptotic bodies, which cause cell membrane rupture, releasing the cytoplasmic contents, specifically the pro-inflammatory cytokines IL-1 and IL-18