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Statements Author contributions H-HS: Conceptualization, Data curation, Investigation, Methodology, Software, Supervision, Writing original draft, Writing review & editing

This was demonstrated in a study which noted that rescue morphine was used more frequently in patients with lower APAP concentrations ( Differences in APAP efficacy among pediatric and adult populations were also observed

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Longitudinal data were assessed using a linear mixed effects model, with group as a categorical variable and time as a continuous variable, and cross sectional data were assessed either by independent samples t -test or one-way ANOVA