Fatigue accompanied by other concerning symptoms including: Persistent dizziness, lightheadedness, or fainting Rapid or irregular heartbeat Shortness of breath or chest pain Severe or unrelenting nausea and vomiting Inability to keep down food or fluids for more than 24 hours Dark urine, markedly reduced urination, or swelling (signs of dehydration or kidney problems) Yellowing of skin or eyes Severe abdominal pain Mood changes, depression, or difficulty concentrating Signs of potential complications require immediate attention: Stop the medication and seek urgent medical care if you experience severe abdominal pain (especially radiating to the back) which could suggest pancreatitis Stop the medication and seek urgent care if you develop symptoms of severe allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing) Symptoms suggesting gallbladder disease (right upper abdominal pain, especially after eating) Hypoglycemia in patients taking diabetes medications (shakiness, sweating, confusion) Inability to meet nutritional needs despite best efforts, or unintentional weight loss exceeding recommended rates (generally more than 1-2 pounds per week after the initial period)

It claimed 'GLP-1s for diabetes could be sold at a profit for just US $0.89 per month, compared to the price of $95 per month charged in Brazil, $115 per month charged in South Africa, $230 charged in Latvia and $353 charged in the US, which is a 39,562% markup over what the estimated generic price could be.' Christa Cepuch, Pharmacist Coordinator at MSF's Access Campaign, argues 'These new drugs are an absolute game changer for people living with diabetes, but are being kept out of the hands of hundreds of millions of people in low- and middle-income countries who need them' (Barber, Gotham, Bygrave
Long-term results and expectations beyond year one Research following semaglutide users beyond one year shows maintained weight loss in those who continue medication, with average losses stabilizing around 15 to 17 percent of starting weight
Agonists tickle and stimulate receptors in the brain, and this drug stimulates glucose-dependent insulin release from the pancreas