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Apply pressure and slowly push the needle into the chosen injection site
However, the SUSTAIN six trial evaluated semaglutide, a GLP-1 analog, in patients with type 2 diabetes and high cardiovascular risk and discovered that semaglutide was associated with a higher incidence of diabetic retinopathy complications compared to placebo, with a hazard ratio (HR) of 1.76, particularly in patients with pre-existing DR ( This seemingly controversial impact of GLP-1RAs on DR may be because most trials focused on microvascular and cardiovascular outcomes rather than DR
Other GLP-1 medications, such as Ozempic (semaglutide) and Mounjaro (tirzepatide), are approved for diabetes but used off-label to help patients lose weight
These products are Schedule H medications they require a valid prescription from a registered medical practitioner
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