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The asymmetry observed on funnel plots may be attributable to methodological heterogeneity, including variation in sample sizes, population differences, and outcome definitions across the included studies
Where GLP-1s Fit in the Menopausal Framework Returning to the framework established in the previous section, the menopausal transition represents a disruption operating on two levels: the upstream withdrawal of hormonal signaling, and the downstream metabolic consequences that withdrawal produces
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