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Cancer cells often produce more endogenous reactive oxygen species (ROS) due to increased cell growth and metabolic demands for oxygen and nutrients (2)
Center for Medicare & Medicaid Services
The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)
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