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It is estimated that many as 50% to 75% of people who take a GLP-1 discontinue it within a year

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Although data from early phase trials suggest that retatrutide is well tolerated with a similar adverse event profile to GLP-1 RAs, additional research assessing long-term safety and efficacy of retatrutide in people living with obesity and/or T2D (including cardiovascular outcomes) is awaited over the next five years

Clinical studies show average triglyceride reductions of 20 to 30 percent in patients with elevated baseline levels, though some experience even larger drops