Additional results from the TRIUMPH program, which include a maintenance dose of 4 mg in addition to the 9 mg and 12 mg doses tested in this trial, are expected in 2026
Oral GLP-1s for obesity saw a recent setback when in April (April 2025), Pfizer announced that it was discontinuing development of danuglipron, an oral GLP-1 receptor agonist, which was being investigated for chronic weight management, due to potential liver toxicity
"The use of these drugs has exploded throughout industrialized countries and they have provided very significant benefits in many ways, but future discussions between a patient and their physician should include NAION as a potential risk," said Rizzo, the studys corresponding author
References Sosne G, Qiu P, Kurpakus-Wheater M