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Additionally, the intrinsic mechanisms of action, primarily ROS generation and labile iron accumulation, pose a significant risk of neurotoxicity
Accordingly, LipRSV, composed of phosphatidylcholine-based PEGylated liposomes with a total lipid concentration of 6 mg/mL and RSV at a final concentration of 1 mg/mL, was selected for animal treatment
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Mitochondrial ROS production and oxidative mtDNA damage is increased during reoxygenation in the GPX1 knockout mice, in addition to structural abnormalities in cardiac mitochondria and myocytes, suggesting GPX1 may play an important role in protecting cardiac mitochondria from reoxygenation damage in vivo
