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When Eli Lilly published retatrutide's Phase 2 trial results in the New England Journal of Medicine in June 2023, the numbers got attention: participants on the highest dose lost an average of 24.2% of their body weight over 48 weeks
Merkel R, Hernandez NS, Weir V, Zhang Y, Caffrey A, Rich MT, et al
A physical exam is usually done to confirm the diagnosis, while blood tests might also be ordered to rule out other conditions that could be causing your symptoms
In the longer-term (i.e., 4 weeks), intragastric administration of DB remained effective at increasing meal-induced GLP-1 secretion, associated with a reduction in body weight in obese mice, whereas another bitter tastant, quinine, had minimal effect on GLP-1 or ghrelin, despite reducing body weight (66)
