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J Clin Endocrinol Metab 78:156164 Staruschenko A, Pochynyuk O, Vandewalle A, Bugaj V, Stockand JD (2007) Acute regulation of the epithelial na+ channel by phosphatidylinositide 3-OH kinase signaling in native collecting duct principal cells

In addition, hyperglycaemia leads to oxidative stress by increasing mitochondrial superoxide production, thereby increasing hexosamine pathway (HBP) activity by 2.4-fold [52]

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Furthermore, it has been reported that approximately 515% of the GSH could be oxidized to GSSG during sample deproteination with acids 60