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10.1172/JCI176660 39 ZhangC.XieY.ChenH.LvL.YaoJ.ZhangM.et al (2020)

Numerous conditions can alter the level of GSH synthesis via changes in glutamate-cysteine ligase activity and expression of the GCLC gene such as oxidative stress, antioxidant levels, hormones, cell proliferation, and diabetes mellitus

Collectively, these findings position glutathione at the convergence of oxidative stress regulation, mitochondrial function, vascular integrity, and cardiometabolic balance

A more individualized response-based approach monitors body composition changes and continues therapy as long as positive progress occurs, adjusting or pausing when plateaus develop or goals are achieved