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Many respond poorly even to 500mcg daily, potentially requiring synthetic growth hormone replacement instead if treatment indicated

Cotadutide (n=12)

We found significant decrease in DNA polymerase kappa (POLK) (log2 fold = 2.987, P = 0.026), CD109 molecule (CD109) (log2 fold = 3.977, P = 0.027), cathelicidin antimicrobial peptide (CAMP) (log2 fold = 5.020, P = 0.012), nucleolar protein interacting with the FHA domain of MKI67 (NIFK) (log2 fold = 5.048, P = 0.019) and serglycin (SRGN) (log2 fold = 6.286, P = 0.009) GP levels compared with the levels before 4-week intermittent fasting

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