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The G-BA assesses the additional clinical benefit relative to an appropriate comparator therapy

Retatrutide targets three hormone receptors : GLP-1, GIP (glucose-dependent insulinotropic polypeptide), and glucagon

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After final selection, data were extracted by three investigators (XX, PPZ, and CXF) from the eligible case reports, which included first authors name, year of publication, country, patient sex and age, medical history, indication for medication, route of administration, dosage, concomitant medications, ADRs, diagnosis, time to ADR onset, clinical presentation, drug re-exposure, intervention measures, laboratory parameters, such as blood urea nitrogen (BUN), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), urine protein-to-creatinine ratio (UPCR), and proteinuria, and patient outcomes