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The baseline characteristics are given in Table 1

Within a decade, that pharmacological argument became tirzepatide, which became Mounjaro, which became Zepbound, which generated billions of dollars in revenue and last year became the first weight-loss drug to outperform semaglutide head-to-head in a Phase 3 trial

Some patients report a temporary increase in fatigue or mild headache in the first few days, which resolves without intervention

Alcohol metabolism induces oxidative stress and hepatocyte injury, triggering DAMP release, inflammatory signalling, inflammasome activation, and impaired hepatic regeneration