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Selenium: Selenium supports glutathione peroxidase, an enzyme that uses glutathione to combat oxidative stress and protect cells

paragallinarum strains reveals an important insight: the ability of the bacterium to cause disease depends on managing oxidative stress

While substantial advances have shaped our understanding of ferroptosis 1 , GPX4-restricted immunologic responses remain poorly explored despite reports of inflammatory tissue injury in GPX4-deficient animals 9,11,27

Many spin traps react relatively ineffectively with superoxide (e.g., PBN has weak in vitro antioxidant activity), so high doses are required to achieve a therapeutic benefit