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The enterocyte FXR is the sensor of luminal bile acids and increases the secretion of the enterohormone fibroblast growth factor 19 (FGF19), which regulates liver bile acid synthesis, systemic glucose metabolism, and gallbladder motility (refilling) by activation of its receptor -klothoFGFR4 [28, 31]

Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome

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This extended duration of action is achieved through structural modifications that protect the molecule from rapid degradation and enhance binding to albumin in the bloodstream