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For participants with HF at baseline, the incidence rate of HF events was lower with oral semaglutide (1.75%) compared to placebo (2.23%), with a hazard ratio (HR) of 0.78 (95% CI: 0.571.07)
But it immediately caveats that sublingual delivery depends on mucosal permeability and saliva flow, and that this variability is exactly why the route requires provider oversight rather than self-selection
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