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It focused on how this compound affects the connection between the gut and the brain, based on findings from three recent animal studies

Its no secret that GLP-1 medications like Ozempic, Wegovy, and Saxenda have become increasingly popular for weight loss

For Canadians dealing with obesity and related metabolic conditions, this development matters because current options, while effective, still leave many patients short of their goals

In addition to GLP-1R agonists, orally administrated DPP4-inhibitors, e.g., sitagliptin and saxagliptin , which are known to potentiate the effect of endogenous GLP-1 by inhibiting its degradation, have also been clinically studied as protective agents against retinopathy (Svenningsson et al., 2016) in T2D patients, although DPP4-inhibitors cannot cross the blood-brain barrier (Mousa and Ayoub, 2019)