Typically, a patient must have a BMI of 30 or greater, or a BMI of 27 or greater with at least one weight-related comorbidity like high blood pressure
The Key Takeaways: Most common: Nausea (43%), manageable with dietary changes and timing Unique: Dysesthesia (20.9%), mild tingling sensations, not seen with Wegovy/Mounjaro Timeline: Worst during dose escalation (weeks 116), significant improvement after Discontinuation: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 the general obesity population tolerates it better than the osteoarthritis cohort Reversible: Stopping medication reverses side effects For most people with obesity especially severe obesity the 28.328.7% weight loss and associated health benefits outweigh the temporary discomfort during the first few months
Mater Today Nano 24:100430 Duman FD, Forgan RS (2021) Applications of nanoscale metalorganic frameworks as imaging agents in biology and medicine
Another double-blinded, placebo-controlled study reported that liraglutide increased intrinsic connectivity in bilateral hippocampal, medial frontal and lateral occipital regions, suggesting that liraglutide might reduce or delay AD progression (245)