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276 Mice with POMC neuron-specific SEL1L depletion develop age-associated obesity and hyperphagia owing to POMC retention within the ER, suggesting that HRD1 complex-mediated ERAD functions in the development of monogenic obesity associated with impaired prohormone folding

2-8C (refrigerator) for routine storage

GLP-1 medications help people lose significant amounts of weight: Most people lose 10-20% of their body weight Clinical studies show average weight loss of 45-50 pounds Weight loss directly improves airway opening during sleep Better Blood Sugar Control When your blood sugar goes up and down all night, it can wake you up or make your sleep restless

41 Article Information Published Online: October 8, 2025