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Week 8 to 12: Skin tone and steady daytime energy become noticeable, the slower-building benefits that show up once the GH pulse has been consistent for weeks

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The complexity of PD origins, however, has been underscored by recent discussions of brain versus gut first etiology, molecular biomarkers, involvement of S, phenotypic characteristics (such as unilateral vs bilateral, or tremor predominant vs akinetic-rigid vs postural instability, and gait disturbance), and genotyping 3,4,6,7

Brorson JR, Schumacker PT, Zhang H