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(31) showed that neurons in the brains of patients with T2DM secrete the regulatory factor angiopoietin-like protein 8 (ANGPTL8) into the hippocampus, which activates microglia to up-regulate pro-inflammatory factors and axonal damage, leading to cognitive impairment

These results confirm that proline at position 3 (P3) is a critical residue for BPC157-mediated endothelial cell proliferation