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Furthermore, ADSC-EVs have shown potential in the regeneration of skin appendages such as hair follicles, exhibiting validated phenotypes and the gene expression profile that supports the outcomes [142]

The stress response to surgery typically raises blood glucose levels, making perioperative diabetes management a careful balance

Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Moore, 1906), and in the 1960s a team of researchers in the UK and the US independently discovered the incretin effect, in which oral glucose markedly stimulates insulin secretion, setting the stage for the subsequent development of incretin (Elrick et al., 1964

The primary outcome was the incremental cost-effectiveness ratio (ICER) (/QALY)