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Pigmentation disorders are the third most common reason for dermatological consultations ( 2.2.1 Ultraviolet exposure UV exposure is critical to skin pigmentation (Koike and Yamasaki, 2020

The tight budget argument, when used, is often a blanket statement referring to the overall pressure on NHS resources, not the specific cost of a single appointment

The analysis of the MD result demonstrates the movement of the drug within the active site owing to the formation of multiple polar interactions and hydrogen bond formation

Human relevance would require sufficient published, peer-reviewed controlled human studies, appropriate regulatory review, pharmacokinetic characterization, toxicology data, and long-term safety evaluation