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Iron overload is highly involved in the pathophysiological process of secondary brain injury reported in recent years ( Iron and Its Metabolism Because of irons hydrophilic feature, the entry of iron from the circulating blood into the brain parenchyma requires effective conveyance through the BBB
Indeed, it is evident that high concentrations of Vitamin B12 are an essential component of a healthy and active lifestyle
Acknowledgements This work was supported by research grants from the National Key Research and Development Program of China (2016YFA0100501), the Chinese National 973 Program (2012CB517502), the National Natural Sciences Foundation of China (81400798, 81400767, 81401142, 81270858, and 81570692), and the Beijing Natural Sciences Foundation of China (7163233)
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