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The activation of PPAR leads to increased expression of the transcriptional co-activator, PGC-1 as well as the genes encoding uncoupling protein-1 (UCP1) and components of mitochondrial oxidative phosphorylation such as cytochrome c (CYCS)
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Human clinical trial data remains limited, but the mechanistic and preclinical evidence base is stronger for gut-related peptides than for most other peptide research categories
Maintaining adequate protein intake and regular resistance exercise remains important for supporting muscle preservation
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