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Visual indicators of AHK-Cu degradation include solution color change from clear or pale blue to dark blue, brown, or yellow, increased cloudiness or precipitate formation, and for unreconstituted powder, clumping or moisture visible in the vial

A reduction in proline (precursor to hydroxyproline) was reported in Diporeia (amphipod) following starvation, serving as a major source of free amino acids for energy production 33