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Increased total sleep time by ~59% vs placebo in a controlled study

Although previous ex vivo studies employing NCI-H716 cells (a human L cell line) [35] or human ileal and colonic tissues [14] were indicative of a direct effect of metformin in stimulating GLP-1 release, clinical evidence suggests that the augmentation of postprandial GLP-1 secretion by metformin is largely indirect