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While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels