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Why it matters: A dosing chart cannot screen for pancreatitis risk, dehydration, pregnancy, medication interactions, or unsafe sourcing

Bien quune proportion assez importante des patients aient rapport un certain nombre deffets secondaires, en particulier au niveau gastro-intestinal (nauses, vomissement, diarrhes), ces effets indsirables ont cependant tendance samenuiser avec le temps et ladhrence au traitement demeure leve, avec environ 5 % des patients qui cessent le traitement en raison des effets secondaires

The margin between therapeutic and toxic doses is extraordinarily wide, and the most common side effects are mild and manageable

The main outcome was a composite measure capturing the occurrence of end-stage renal disease or a 40-percent decline in the glomerular filtration rate