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These metabolites accumulate when b12 function becomes inadequate, sometimes before serum b12 drops below normal range

Following this, we recommend a maintenance B12 shot every 3-4 weeks to maintain B12 levels and support optimum wellness

(NOTE: There is an ongoing debate about whether 5-Amino 1MQ should be classified as a small molecule or a peptide, but thats a discussion far beyond the scope of this article) It was discovered in 2017 by researchers at the University of Texas who were attempting to discover small, selective, and membrane-permeable inhibitors of an enzyme called nicotinamide N -methyltransferase (NNMT)