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Two distinct medication classes have emerged as evidence-backed options for weight management: bupropion, an antidepressant that increases norepinephrine and dopamine, and GLP-1 receptor agonists, which regulate appetite hormones
Gastrointestinal side effects include: Nausea (15-30% of patients depending on dose): Usually mild to moderate and decreasing over time Diarrhea (13-24%): May contribute to dehydration if persistent Vomiting (6-12%): More common at higher doses Constipation (5-17%): Can alternate with diarrhea in some patients Abdominal pain (6-10%): Typically mild and self-limiting Decreased appetite : An intended effect contributing to weight loss Hypoglycemia risk varies depending on concurrent medications
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