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In addition, neuroimaging studies of patients with ADHD reported an elevated level of striatal dopamine transporter activity, which is reverted by the administration of methylphenidate [59, 60]
The second is the inflammation-apoptosis dual inhibition barrier: blocking the NF-B/p38-MAPK/COX-2/iNOS inflammatory cascade, attenuating the inflammatory response through the dual regulation of STAT3/STAT1 and inhibiting the JNK/p53-mediated pro-apoptotic signaling and regulating the balance of Bcl-2/Bax/caspase-3, which is the most effective way to reduce the inflammatory response in mitochondria and ferroptosis
What followed was about a year of deep research, listening to David Schmidt, reading everything I could find, and eventually working closely with many clients on their own patch journeys
Neuron 108 , 691706.e610 (2020)
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