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Substrate Discrimination in Promiscuous Enzymes GSTs, like many other enzymes involved in detoxication, are promiscuous such that they can act on several different substrates and catalyze many alternative chemical reactions
Notably, the azo-containing chemotherapeutic drug procarbazine for the treatment of Hodgkins lymphoma and brain cancers was found to interact through a similar mechanism of action involving the transformation of GSH to GSSG and regeneration of the catalyst through a reaction with O 2 38,39 , providing feasibility of the proposed catalysis
Thus, sorafenib is regarded as the first-line treatment in advanced HCC patients with a manageable adverse event (Llovet et al., 2008)
Are GLP-1 medications available in pill form
