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A major ROS source in response to ATII is Nox1 in the vascular smooth muscle layer
In addition to thiamines role as a precursor of an essential coenzyme in energy production from glucose oxidation (24), contribution to gastrointestinal function of the non-coenzyme action of thiamine (25, 26), presumably regulating not only the coenzyme-dependent pathway of acetylcholine (ACh) biosynthesis (27), but also ACh signaling at neuromuscular junctions (28) and in non-neuronal cells (29), is considered
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