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Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: do we have to revise current definitions of acute renal failure

At a glance Drug / alendronate (Fosamax), oral bisphosphonate for osteoporosis Supplement / glutathione, endogenous antioxidant tripeptide (glycine-cysteine-glutamate) Known direct interaction / none reported in peer-reviewed pharmacokinetic studies as of 2025 Primary risk / indirect: oral glutathione taken near alendronate may worsen already-poor bisphosphonate absorption Alendronate fasting bioavailability / approximately 0.6% of oral dose reaches systemic circulation Recommended separation window / minimum 30 minutes before or 2 hours after alendronate dosing IV or liposomal glutathione / no chelation data available

Nanoparticle for lymph node specific imaging and identification For most malignant tumors, the presence of lymph node metastasis is of great significance in guiding treatment and improving prognosis [102]