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It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element
However, in controlled clinical studies in adults (n = 3890) and a controlled clinical study in pediatric patients (n = 349), subgroup analyses based on age, race, BMI and gender did not show differences in safety and efficacy between insulin glargine and NPH insulin [see Clinical Studies ]
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