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Senolytics, which are agents that selectively eliminate senescent cells, and ferroptosis inhibitors, which target iron-dependent cell death pathways implicated in cartilage degeneration, are emerging as potential disease-modifying therapies

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Additionally, the experiments were conducted in accordance with the Animal Research: Reporting of in Vivo Experiments (ARRIVE) guidelines [76] for the care and use of research animals

Endocrine feedback and receptor interactions: Studies focused on feedback regulation, receptor desensitization and cross-talk between ghrelin, GHRH and somatostatin pathways under dual-secretagogue stimulation