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But if you weight effectiveness as a function of risk/benefit, not just pigment density, the picture changes: a slightly milder tan produced by a more selective, clinically studied drug may be preferable to the dramatic but pharmacologically messy profile of Melanotan IIespecially when the latter is sourced from unregulated research chemical suppliers

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From a more general point of view, it is particularly interesting that these drugs exert their therapeutic action by acting on the brain to reduce appetite and thus create a significant caloric deficit

Tirzepatide is sometimes discussed alongside traditional GLP-1 medications, although it acts on both GLP-1 and another hormone pathway called GIP