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Gallbladder In the SCALE-trial, high-dose liraglutide for the treatment of obesity was associated with an increased risk of gallbladder events compared to placebo (2.5% versus 1.0% of patients, respectively) ( versus 0.1% with placebo), while the risk of cholecystitis was similar (data derived from the summary of product characteristics (SmPC) ( Initially the gallbladder events were attributed to GLP-1RA-induced weight loss, as for example in the SCALE and LEADER trials, the patients with gallbladder events had more than average weight loss ( Cardiovascular All GLP-1RAs increase heart rate, and this is not different for semaglutide
The study was supported by Slovenian Research Agency grants #P3-0298, #P3-0343
Conditions like Hashimotos, rheumatoid arthritis, lupus, psoriasis, and inflammatory bowel disease often involve gut dysfunction, nutrient deficiencies, chronic inflammation, infections, and environmental triggers
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