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Med 384 , 989 (2021)

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McAleer MF, Smith GL, Smith BD, Swisher SG , Ajani J, Komaki R, Cox JD, Buchholz TA

While SURPASS-4 was not powered to evaluate differences in MACE-4 incidence between tirzepatide treatment groups and glargine, it was designed to fulfill the MACE-4 non-inferiority analysis requested by regulatory authorities to evaluate the cardiovascular safety of new glucose lowering medications