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For example, enteric neurons express glutamate transporters and are in close proximity to VANs expressing glutamate-sensitive receptors 75
The findings were independent of overweight/obesity category at baseline, as seen in this subgroup analysis for the primary endpoint
The researchers suggest that changes in gut microbiome composition, particularly involving Akkermansia muciniphila and Parabacteroides distasonis , may explain the effects on GLP-1 and other gut-brain signaling molecules
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