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Neuromodulation of obesity and ferroptosis The nervous system is known to play a leading role in the regulation of physiological functional activities, but is also closely related to AT as a result of the dynamic crosstalk between adipocytes and other types of cells in the highly neurologically innervated and vascularized tissue matrix (83)

96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis

And that benefit might even extend to people with PCOS who dont have a high weight but are insulin-resistant, Dr