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In the SURMOUNT-1 trial published in the New England Journal of Medicine , once-weekly Tirzepatide produced dose-dependent reductions in body weight over 72 weeks in adults with obesity or overweight, with the highest-dose arm showing some of the strongest weight-loss outcomes reported at the time for an incretin-based therapy
This years 2026 American Society of Clinical Oncology (ASCO) Annual Meeting revealed two such studies
Biological mechanisms that promote weight regain following weight loss in obese humans
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