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East Asia: In East Asia, China and Japan are experiencing strong demand for GLP-1 receptor agonists, driven by an increasing prevalence of type 2 diabetes and expanding access to diabetes treatments

The CMS BALANCE (Better Approaches to Lifestyle and Nutrition for Comprehensive Health) pilot program, announced in December 2025, aims to begin expanding Medicare access to obesity medications by mid-2026, with a broader Part D model rolling out in January 2027

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In these cases, the introduction of semaglutide might smooth out the diarrheal phases but could potentially lengthen the constipation phases