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The GLP-1 landscape is experiencing a significant shift, with Canada leading the way

[5] A 2018 comprehensive review summarized the effects of supplemental L-carnitine on exercise performance and recovery in well-trained athletes (aged 1636 years) and recreationally active adults (aged 1850 years)

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The rationale is elegant: because GLP-1 receptors are enriched in metabolically active brain regions, using GLP-1 as a delivery vehicle allows estrogen to be directed preferentially toward the central nervous system, potentially enhancing its neuroprotective effects while limiting systemic hormonal exposure