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Our goal was to focus on how mitochondria facilitate the acute stress response to 5FU in cells that tolerated treatment (that is, were not sensitive enough to treatment to die)

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Despite the report that ARC GLP-1 signaling regulates glucose metabolism but not feeding behavior [61], it has also been shown that GLP-1R agonist liraglutide infusion in the ARC induces weight loss in rodents [33]

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For women with PCOS or during menopause, GLP-1 may help support metabolic changes that are often hard to shift, but it isnt a standalone solution

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LEADER trial (Marso 2016, PMID 27295427) reported 13% reduction in MACE in T2D patients with high cardiovascular risk

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